New Study Reveals Link Between Cannabis Use and Epigenetic Changes
A recent study of over 1,000 adults has found a connection between cannabis use and changes in the epigenome, a complex system that regulates gene expression. The epigenome acts like a set of switches, turning genes on or off to influence various bodily functions.
Researchers from Northwestern University analyzed blood samples from participants who had reported their cannabis use over a 20-year period. The samples were taken five years apart, at the 15- and 20-year marks. The study found that people who used cannabis regularly or had used it extensively had changes in their epigenetic markers, specifically DNA methylation levels.
DNA methylation is a process where methyl groups are added or removed from DNA, affecting gene activity. This modification can be triggered by environmental and lifestyle factors, including cannabis use. The changes can be passed on to future generations and can provide clues about recent and historical exposures.
The study identified numerous DNA methylation markers associated with recent and cumulative cannabis use. Interestingly, one marker was found to be linked to tobacco use, suggesting a potential shared epigenetic regulation between the two substances.
Previous research has linked epigenetic changes associated with cannabis use to various health issues, including cellular proliferation, hormone signaling, infections, neurological disorders, and substance use disorders. However, this study does not prove that cannabis directly causes these changes or health problems.
The researchers emphasized the need for further studies to determine whether the associations between cannabis use and epigenetic changes are consistent across different populations. They also suggested that examining the effects of cannabis on age-related health outcomes could provide valuable insights into the long-term impact of cannabis on health.
The study was published in the journal Molecular Psychiatry and provides new insights into the relationship between cannabis use and epigenetic factors.
